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参考资料(来源文献)
| 背景描述 | NCI-H526 [H526] is an epithelial cell line that was isolated from the lungs of a 55-year-old, White male with carcinoma.NCI-H526 expresses elevated levels of 2 biochemical markers of SCLC: neuron specific enolase and the brain isoenzyme of creatine kinase. They do not express L-dopa carboxylase or bombesin-like immunoreactivity. These cells express the c-kit gene as well as the N-myc gene, but not c-myc or L-myc. N-myc is amplified and p75 c-myb expression was observed. NCI-H526 also expresses the proto-oncogenes N-ras, Ki-ras, Ha-ras, and c-raf1. Only trace amounts of the retinoblastoma susceptibility gene, RB mRNA were detected. RB protein was not detected. The cells express easily detectable levels of p53 mRNA compared to levels found in normal lung. Abnormally sized mRNA was present. |
| 年龄（性别） | 男性；55岁 |
| 组织来源 | 肺 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 小细胞肺癌 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | 36-48 hours |
| 致瘤性 | Yes; Yes, the cells produce tumors in athymic nude mice |
| 保藏机构 | ATCC; CRL-5811 |
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