本司产品仅用于科研,不用于临床诊断和治疗

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BMP-2/LEM/MCF, Human, Recombinant

货号:PCK273

价格:¥980¥¥

规格:
10μg
  • 10μg
数量: - +

产品信息

别名 Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
物种 Human
表达宿主 E.coli
序列信息 MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR with polyhistidine tag at the C-terminus
检索号 P12643
分子量 13.76 kDa
表观分子量 14 kDa
标签 His-tag at the C-terminus
生物活性 Measure by its ability to induce alkaline phosphatase production by ATDC5 cells.The ED50 for this effect is <9.5 ng/mL.The specific activity of recombinant BMP-2 is > 3.2 x 10^6IU/mg.

产品特性

纯度 >95% as determined by SDS-PAGE. Ni-NTA chromatography.
内毒素 <0.1 EU per 1 μg of the protein by the LAL method.
保存 Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution, store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1%BSA,10%FBS,5%HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months.
运输 Ambient temperature or ice pack.
制剂 The protein was lyophilized from a 0.2 µm filtered solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5.
复融 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL.Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

背景介绍

BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition. Like many other proteins from the BMP family, BMP-2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2 may be involved in white adipogenesis and may have metabolic effects.
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