本司产品仅用于科研,不用于临床诊断和治疗

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BMP-15/GDF-9B/ODG2/POF4, Human, Recombinant

货号:PCK280

价格:¥980¥¥

规格:
10μg
  • 10μg
数量: - +

产品信息

别名 Growth/Differentiation Factor-9B, GDF-9B, ODG2, POF4
物种 Human
表达宿主 E.coli
序列信息 MQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR with polyhistidinetag at the C- terminus
检索号 O95972
分子量 14.88 kDa
表观分子量 13-18 kDa
标签 His-tag at the C-terminus
生物活性 Measure by its ability to induce alkaline phosphatase production by ATDC5 cells.The ED50 for this effect is <17 ng/mL.

产品特性

纯度 >98% as determined by SDS-PAGE. Ni-NTA chromatography
内毒素 <0.1 EU per 1 μg of the protein by the LAL method.
保存 Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution, store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1%BSA,10%FBS,5%HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months.
运输 Ambient temperature or ice pack.
制剂 The protein was lyophilized from a 0.2 µm filtered solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5.
复融 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL.Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

背景介绍

Bone morphogenetic protein 15 is a protein, that in humans, is encoded by the BMP15 gene. It's mainly involved in folliculogenesis. The protein encoded by this gene is a member of the TGF-β superfamily. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. This protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.
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