本司产品仅用于科研,不用于临床诊断和治疗

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BMP-7, Human, Recombinant

货号:PCK372

价格:¥188073803668051880

规格:
10μg
  • 10μg
  • 50μg
  • 500μg
  • 1mg
数量: - +

产品信息

别名 bone morphogenetic protein 7, Osteogenic Protein-1 (OP-1), BMP7
物种 Human
表达宿主 E.coli
序列信息 MANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH with polyhistidine tag at the C-terminus.
检索号 P18075
分子量 14.00 kDa
表观分子量 12 kDa
标签 His Tag (C-term)
生物活性 Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is < 0.65 μg/mL.

产品特性

纯度 >95% as determined by SDS-PAGE. Ni-NTA chromatography.
内毒素 <0.1 EU per 1 μg of the protein by the LAL method.
保存 Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution, store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1% BSA, 10% FBS, 5% HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months.
运输 Ambient temperature or ice pack.
制剂 The protein was lyophilized from a 0.2 µm filtered solution containing 1× PBS, pH8.0.
复融 It is recommended to reconstitute the lyophilized protein in sterile water to aconcentration not less than 100 μg/mL. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

背景介绍

Bone Morphogenetic Protein-7 (BMP-7) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP7 can significantly inhibit TGF-β through binding with TGF-β receptor and trigger SMAD transcription factors, such as SMAD 1/5/8. It plays a vital role in inhibiting the expansion of kidney damage and promoting the differentiation of osteoblasts.
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