本司产品仅用于科研,不用于临床诊断和治疗

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GM-CSF/ CSF2 (C-6His, Cells), Human, Recombinant

货号:PCK037

价格:¥1280¥3280¥1748025680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +

产品信息

别名 Granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; CSF
物种 Human
表达宿主 Human Cells
序列信息 Ala18-Glu144
检索号 P04141
分子量 15.5 kDa
表观分子量 17-30 kDa
标签 C-6His
生物活性 Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells.The ED50 for this effect is 6-30 pg/ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输 Ambient temperature or ice pack.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a Growth Factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to Cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a Growth Factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.
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