产品信息
| 别名 | Tumor necrosis factor Ligand superfamily member 11; Tnfsf11; Osteoclast differentiation factor; ODF; Osteoprotegerin Ligand; OPGL; Receptor activator of nuclear factor kappa-B Ligand; RANKL; TNF-related activation-induced Cytokine; TRANCE; CD254 |
| 物种 | Mouse |
| 表达宿主 | Human Cells |
| 序列信息 | Arg43-Asp287 |
| 检索号 | BAA97257.1 |
| 分子量 | 28.3kDa |
| 表观分子量 | 30-35 kDa |
| 标签 | N-6His |
| 生物活性 | Loaded Recombinant Human OPG-Fc on Pro A Biosensor, can bind Mouse RANKL-His with an affinity constant of 1.02 pM as determined in BLI assay. |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Hepes-NaOH, 50mM NaCl, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 8.0. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Mouse tumor necrosis factor Ligand superfamily member 11 (Tnfsf11) is a member of the tumor necrosis factor (TNF) Cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This Cytokine can bind to TNFRSF11B/ OPG andTNFRSF11A/ RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
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