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RANK L/ TRANCE/ TNFSF11 (N-6His), Mouse, Recombinant

货号:PCK061

价格:¥1780¥4980¥1748027980

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +

产品信息

别名 Tumor necrosis factor Ligand superfamily member 11; Tnfsf11; Osteoclast differentiation factor; ODF; Osteoprotegerin Ligand; OPGL; Receptor activator of nuclear factor kappa-B Ligand; RANKL; TNF-related activation-induced Cytokine; TRANCE; CD254
物种 Mouse
表达宿主 Human Cells
序列信息 Arg43-Asp287
检索号 BAA97257.1
分子量 28.3kDa
表观分子量 30-35 kDa
标签 N-6His
生物活性 Loaded Recombinant Human OPG-Fc on Pro A Biosensor, can bind Mouse RANKL-His with an affinity constant of 1.02 pM as determined in BLI assay.

产品特性

纯度 >90% as determined by reducing SDS-PAGE.
内毒素 <1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输 Ambient temperature or ice pack.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM Hepes-NaOH, 50mM NaCl, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 8.0.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Mouse tumor necrosis factor Ligand superfamily member 11 (Tnfsf11) is a member of the tumor necrosis factor (TNF) Cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This Cytokine can bind to TNFRSF11B/ OPG andTNFRSF11A/ RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
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