产品信息
| 别名 | Transforming Growth Factor beta-2; TGFB2; Polyergin; G-TSF; Glioblastoma-Derived T-cell suppressor factor; Cetermin; BSC-1 cell growth inhibitor; TGF-beta-2 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ala303-Ser414 |
| 检索号 | P61812 |
| 分子量 | 12.7 kDa |
| 表观分子量 | 12 kDa |
| 生物活性 | Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 cells.The ED50 for this effect is 30-180pg/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 4 mM HCl. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Transforming Growth Factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated Protein. It is known to suppress the effects of Interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).
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