产品信息
| 别名 | TGF-beta Receptor type-2; TGF-beta type II Receptor; TGFBR2; Transforming Growth Factor-beta Receptor type II |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Thr23-Asp159 |
| 检索号 | P37173 |
| 分子量 | 42.6 kDa |
| 表观分子量 | 59 kDa |
| 标签 | C-Fc |
| 生物活性 | Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 18.41 ng/ml in the presence of 100pg/ml of recombinant human TGF-beta 1. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
TGFBR2 is a single-pass type I membrane Protein and contains one Protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another Receptor Protein and binds TGF-beta. Signals triggered through the TGF-beta Receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta Receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.
