产品信息
| 别名 | Activin Receptor Type-2A; Activin Receptor Type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ala20-Pro134 |
| 检索号 | P27037 |
| 分子量 | 14.35 kDa |
| 表观分子量 | 28-38 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C,stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Supplied as a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, 10% Glycerol, 5% Trealose, pH7.4. |
背景介绍
Activin Receptor Type-2A is a Protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activintype 2 Receptor. This gene encodes activin A type II Receptor. Activins are dimeric growth anddifferentiation factors which belong to the transforming Growth Factor-beta (TGF-beta) superfamily ofstructurally related signaling Proteins. Activins signal through a heteromeric complex of Receptor serinekinases which include at least two type I (I and IB) and two type II (II and IIB) Receptors. These Receptors areall transmembrane Proteins, composed of a Ligand-binding extracellular domain with cysteine-rich region, atransmembrane domain, and a cytoplasmic domain with predicted serine/ threonine specificity. Type IReceptors are essential for signaling; and type II Receptors are required for binding Ligands and forexpression of type I Receptors. Type I and II Receptors form a stable complex after Ligand binding, resultingin phosphorylation of type I Receptors by type II Receptors. Type II Receptors are considered to beconstitutively active kinases.
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