产品信息
| 别名 | Tumor necrosis factor Ligand superfamily member 13; A proliferation-inducing Ligand; APRIL; TNF- and APOL-related leukocyte expressed Ligand 2; TALL-2; TNF-related death Ligand 1; TRDL-1; CD256; TNFSF13 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Lys112-Leu250 |
| 检索号 | O75888 |
| 分子量 | 50 kDa |
| 表观分子量 | 60 kDa |
| 生物活性 | Immobilized Human APRIL -Flag-His at 1μg/ml (100 μl/well) can bind Cynomolgus BCMA-Fc.The ED50 of Cynomolgus BCMA-Fc is 4.23 ng/ml. |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 1M NaCl, pH8.3. |
| 复融 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
APRIL (a proliferation-inducingLigand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF Ligand superfamily. It issynthesized as a32 kDa pro Protein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule.Secreted human APRIL, which consists almost entirely ofa single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. BothAPRIL and its close relative BAFF bind and signalthrough the TNF superfamily Receptors TACI and BCMA, while BAFF additionally functions through BAFF R.APRIL binds to heparan sulfateproteoglycans (HSPGs) independently of its binding to TACI and BCMA.
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