产品信息
| 别名 | Tumor necrosis factor Receptor superfamily member 8; CD30L Receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Phe19-Lys379 |
| 检索号 | P28908 |
| 分子量 | 65.2 kDa |
| 表观分子量 | 90-120 kDa |
| 标签 | C-Fc |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
CD30, also known as TNFRSF8, is a cell membrane Protein of the tumor necrosis factor Receptor family, which regulates proliferation/ apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its Ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
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