产品信息
| 别名 | Fibroblast Growth Factor Receptor 3; FGFR-3; CD333; FGFR3; JTK4; IIIc |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Glu23-Gly375 |
| 检索号 | P22607 |
| 分子量 | 64.8 kDa |
| 表观分子量 | 95-110 kDa |
| 生物活性 | Immobilized Human FGF-12 at 2ug/ml (100 μl/well) can bind Human FGFR3-Fc. The ED50 of Recombinant Human FGFR3-Fc is 0.5-4 ug/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Fibroblast Growth Factors (FGFs) are involved in a multitude of physiological and pathological cellular processes. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after Ligand binding. Four distinct genes encoding closely related FGF Receptors, FGF R1-4, are known. All four genes for FGF Rs encode Proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1-3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in Receptors containing all three Ig domains, referred to as the α isoform, or only IgII and IgIII, referred to as the β isoform. Only the α isoform has been identified for FGF R3 and FGF R4. Additional splicing events for FGF R1-3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF Receptors with alternative IgIII domains (IIIb and IIIc). The complex patterns of expression of these Receptors as well as the specificity of their interactions with the various FGF Ligand family members are under investigation.
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