产品信息
| 别名 | CD215; IL15RA; CD215 antigen; IL-15 Receptor subunit alpha; IL-15RA; IL-15R-alpha; Interleukin 15 Receptor; alpha; Interleukin-15 Receptor subunit alpha; MGC104179 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ile31-Thr172 |
| 检索号 | Q13261-3 |
| 分子量 | 42.2 kDa |
| 表观分子量 | 60-75 kDa |
| 标签 | C-Fc |
| 生物活性 | Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 0.35-3.5 ng/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glyco Protein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” Cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/ IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 Receptor β and γ heterodimers and enables signaling to cells.
