产品信息
| 别名 | Interleukin-23 Receptor; IL23R; IL-23 Receptor; IL-23R |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Gly24-Asp353 |
| 检索号 | Q5VWK5 |
| 分子量 | 65.0 kDa |
| 表观分子量 | 90-120 kDa |
| 标签 | C-Fc |
| 生物活性 | Immobilized Human IL-23R-Fc at 10μg/ml (100 μl/well)can bind Human IL-23-His.The ED50 of Human IL-23-His is 0.248 ug/ml. |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin 23 Receptor (IL23R) is a type I Cytokine Receptor for IL23. IL23 Receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several Cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves' s ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
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