产品信息
| 别名 | Interferon gamma Receptor 1; IFNGR1; CDw119; CD119 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Glu18-Ser245 |
| 检索号 | P15260 |
| 分子量 | 26.8 kDa |
| 表观分子量 | 40-50 kDa |
| 标签 | C-6His |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C,stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 运输 | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
背景介绍
Interferon gamma Receptor 1 (IFNGR1) encoded by the IFNGR1 gene, is a single-pass type 1 membrane Protein which belongs to the type II Cytokine Receptor family. IFNGR1 is phosphorylated at Ser/ Thr residues after translation. IFNGR1 is a Receptor for interferon gamma, two Receptors bind one interferon gama dimer. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
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