产品信息
| 别名 | Interleukin-1 Receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 Receptor alpha; IL-1R-alpha; p80; CD121a |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Leu18-Thr332 |
| 检索号 | P14778 |
| 分子量 | 37.0 kDa |
| 表观分子量 | 48-66 kDa |
| 标签 | C-6His |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin 1 Receptor, type I (IL-1R1) is an Interleukin Receptor that belongs to the Interleukin-1 Receptor family. IL-1R1 is an 80 kDa transmembrane Protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a Cytokine Receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many Cytokine induced immune and inflammatory responses. It binds to Interleukin-1 associates with the corecptor IL1RAP to form the high affinity Interleukin-1 Receptor complex which mediates Interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the Receptor/ coReceptor subunits. It also binds Ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. An IL1 Receptor accessory Protein that can heterodimerize with the Type I Receptor in the presence of IL1α or IL1β but not IL1ra, was identified. Recombinant IL1 soluble Receptor Type I is a potent antagonist of IL1 action.
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