产品信息
| 别名 | Interleukin-15 Receptor subunit alpha; Il15ra; sIL-15 Receptor subunit alpha |
| 物种 | Mouse |
| 表达宿主 | Human Cells |
| 序列信息 | Gly33-Lys205 |
| 检索号 | Q60819 |
| 分子量 | 45.5 kDa |
| 表观分子量 | 60-90 kDa |
| 标签 | C-Fc |
| 生物活性 | Measured by its ability to block human IL-15-induced proliferation of CTLL-2 mouse cytotoxic T cells.The ED50 for this effect is 0.5-2 ng/ml. |
产品特性
| 纯度 | >90% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Mouse Interleukin-15 Receptor subunit alpha, also known as Il15ra, is a high-affinity Receptor for Interleukin-15. Il15ra associates as a heterotrimer with the IL-2 Receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the Receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.
