本司产品仅用于科研,不用于临床诊断和治疗

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IFNβ 1a/IFNB1, Human, Recombinant

货号:PCK276

价格:¥980¥¥

规格:
10μg
  • 10μg
数量: - +

产品信息

别名 IFNB1, Type I Interferon
物种 Human
表达宿主 E.coli
序列信息 MSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN with polyhistidine tag at the C-terminus.
检索号 P01574.1
分子量 20.84 kDa
表观分子量 15 kDa
标签 His-tag at the C-terminus
生物活性 Measure by its ability to induce apoptosis in HeLa cells.The ED50 for this effect is <15 ng/mL.Measure by its ability to induce cytotoxicity in TF-1 cells. The ED50 for this effect is <0.1 ng/mL. The specific activity of recombinant human IFN beta 1a is approximately >1 x10^7 IU/ mg.

产品特性

纯度 >98% as determined by SDS-PAGE. Ni-NTA chromatography
内毒素 <0.1 EU per 1 μg of the protein by the LAL method.
保存 Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution, store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1%BSA,10%FBS,5%HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months.
运输 Ambient temperature or ice pack.
制剂 The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0.
复融 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL.Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

背景介绍

Interferon-beta is, a cytokine, released by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. IFN beta 1a conducts through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice are easier to suffer from experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS).In addition, IFN-beta has been proved to suppress the Th17 cell response in both MS and EAE and is usually used to treat MS disease.
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