本司产品仅用于科研,不用于临床诊断和治疗

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IL-23 p19/IL-23/IL-23A/SGRF, Human, Recombinant

货号:PCK278

价格:¥980¥¥

规格:
10μg
  • 10μg
数量: - +

产品信息

别名 IL-23, IL-23A, SGRF
物种 Human
表达宿主 E.coli
序列信息 RAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP with polyhistidine tag at the N-terminus.
检索号 Q9NPF7.1
分子量 19.49 kDa
表观分子量 17 kDa
标签 His-tag at the N-terminus
生物活性 Measured by its ability to induce IL-17 secretion in mouse splenocytes.The ED50 for this effect is <0.5 ng/mL.

产品特性

纯度 >95% as determined by SDS-PAGE. Ni-NTA chromatography.
内毒素 <0.1 EU per 1 μg of the protein by the LAL method.
保存 Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution, store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1%BSA,10%FBS,5%HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months.
运输 Ambient temperature or ice pack.
制剂 The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0.
复融 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL.Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

背景介绍

IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration into tumours. IL-23 mediates its effects on both innate and adaptive arms of the immune system that express the IL-23 receptor. Th17 cells represent the most prominent T cell subset that responds to IL-23, although IL-23 has been implicated in inhibiting the development of regulatory T cell development in the intestine. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of other proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.
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