本司产品仅用于科研,不用于临床诊断和治疗

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IGF-I/ IGF1/ MGF, Human, Recombinant

货号:PCK017

价格:¥500¥1180¥18802580

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +

产品信息

别名 Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1
物种 Human
表达宿主 E.coli
序列信息 Gly49-Ala118
检索号 P05019
分子量 7.6 kDa
表观分子量 8-12 kDa

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输 Ambient temperature or ice pack.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM NaAc-HAc, pH 4.5
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 50mM Acetic Acid.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Insulin-Like Growth Factor I (IGF1) belongs to the family of Insulin-Like Growth Factors that are structurally homologous to proInsulin. Mature IGFs are generated by proteolytic processing of inactive precursor Proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the Insulin Receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
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