产品信息
| 别名 | Erythropoietin; Epoetin; EPO |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ala28-Arg193 |
| 检索号 | P01588 |
| 分子量 | 19.2 kDa |
| 表观分子量 | 30-40 kDa |
| 生物活性 | Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells.The ED50 for this effect is 80-250 pg/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复融 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Erythropoietin (EPO) is a glyco Protein hormone that is principally known for its role in erythropoiesis,where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells.Erythropoietin is a member of the EPO/ TPO family. It is a secreted, glycosylated Cytokine composed of fouralpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytescan only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals aremaintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by theliver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation ofsmooth muscle, neural protection during hypoxia, and stimulation of certain B cells. Genetic variation inerythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These arepathological conditions that develop in numerous tissues and organs as a consequence of diabetesmellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, anddiabetic neuropathy.
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