产品信息
| 别名 | Interleukin-4 Receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha |
| 物种 | Cynomolgus |
| 表达宿主 | Human Cells |
| 序列信息 | Met26-Arg232 |
| 检索号 | G7Q0S7 |
| 分子量 | 24.6 kDa |
| 表观分子量 | 38-58kDa |
| 生物活性 | Measured by its ability to inhibit IL-4-dependent proliferation of TF‑1 human erythroleukemic cells.The ED50 for this effect is 2.38ng/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin-4 Receptor subunit alpha (IL-4RA), alos known as Soluble IL-4 Receptor subunit alpha, belongs tothe type I Cytokine Receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functionsas Receptor for both Interleukin 4 and Interleukin 13 and couples to the JAK1/ 2/ 3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/ IL13 responses are involved in regulating IgEproduction and Chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin Receptor substrates, IRS1/ IRS2. The functional IL4 Receptor isformed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gammachain. In immune cells, IL-4RA creates a type I Receptor. In non-immune cells, it forms a type II Receptorwith of IL13RA1. IL4R can also interact with the IL13/ IL13RA1 complex to form a similar type II Receptor andinteracts with the SH2-containing phosphatases, PTPN6/ SHIP1, PTPN11/ SHIP2 and INPP5D/ SHIP.
