产品信息
| 别名 | Tyrosine- Protein kinase Lyn (LYN); Lck/ Yes-related novel Protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn and JTK8; |
| 物种 | Cynomolgus |
| 表达宿主 | Human Cells |
| 序列信息 | Lys28-Ala214 |
| 检索号 | XM_005545122.1 |
| 分子量 | 21.3 kDa |
| 表观分子量 | 35-50 kDa |
| 生物活性 | Loaded Biotinylated Cynomolgus OX40-His on HIS1K Biosensor, can bind Human OX40L-mFc with an affinity constant of 0.05nM as determined in BLI assay. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
LYN contains one Protein kinase domain, one SH2 domain, one SH3 domain, and the Protein kinase domain plays an important role in its localization in the cell membrane. LYN is also thought to participate in signal transduction from cell surface Receptors that lack intrinsic tyrosine kinase activity. In addition, LYN is associated with a number of cell surface Receptors including the B cell antigen Receptor and immunoglobulin E Receptor (FceRI).
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