产品信息
| 别名 | ABCD-2; CC Chemokine TARC; C-C Motif Chemokine 17; CCL17; Chemokine (C-C Motif) Ligand 17; MGC138273; SCYA17MGC138271; small inducible Cytokine subfamily A (Cys-Cys), member 17; Small-inducible Cytokine A17; T cell-directed CC Chemokine; TARC; TARCA- |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ala24-Ser94 |
| 检索号 | Q92583 |
| 分子量 | 9.1 kDa |
| 表观分子量 | 13 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
C-C Motif Chemokine 17 (CCL17) is a novel CC Chemokine, it belongs to the intercrine beta (Chemokine CC) family. CCL17 is expressed at high levels in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Among CC Chemokine family members, CCL17 has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1 alpha, MIP-1 beta, MCP-1, MCP-2 and MCP-3. CCL17 has been identified to be Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. CCL17 plays a role in T-cell development in thymus and in trafficking and activation of mature T-cells.
